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KMID : 1007520100190010229
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Food Science and Biotechnology
2010 Volume.19 No. 1 p.229 ~ p.233
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Protective Effect of Volatile Extract from Pinus densiflora against Aflatoxin B1-induced Oxidative Stress in HepG2 Cells
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Lee Joon-Kyoung
Chang Hyun-Joo
Chun Hyang-Sook
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Abstract
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Pinus densiflora is one of the traditional medicinal plants found in the East Asia, which has a diversity of biological activities including antioxidant effect. The protective effects of a volatile extract from Pinus densiflora (VEPN) against aflatoxin B1 (AFB1)- induced oxidative stress were investigated in human hepatoma cell line, HepG2. Treatment of HepG2 with VEPN significantly reduced the levels of intracellular reactive oxygen species, thiobarbituric acid reactive substances and 8-hydroxy-2'-deoxyguanosine elevated by AFB1, but it increased the level of reduced glutathione. These results indicate that VEPN may afford cytoprotection by attenuating AFB1-induced oxidative stress.
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KEYWORD
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volatile extract from the Pinus densiflora (VEPN), aflatoxin B1, reactive oxygen species, glutathione, 8-hydroxy-2'-deoxyguanosine
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